Despite a successful national salt iodinization programme, endemic goitre still persists in Iranian children. In a cross-sectional study in Arak the prevalence of goitre was 5.2% in a sample of 6520 primary-school children. Subsamples of 193 children with goitre and 151 healthy children were assessed for urinary iodine excretion, thyroid hormone profile, insulin-like growth factor-1 (IGF-1) and serum zinc. The mean urinary iodine levels of goitrous children and healthy children were 17.4 ug/dL and 15.3 ug/dL respectively, suggesting that iodine consumption was adequate. No significant differences were found between goitrous and healthy schoolchildren in mean levels of urinary iodine, serum IGF-1 or serum zinc. Other factors need be evaluated to explain the residual prevalence of goitre.
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Rezvanfar, M. R., Farahany, H., Rafiee, M., & Eshratee, B. (2010). Insulin-like growth factor-1 and zinc status of goitrous primary-school children in Arak, Islamic Republic of Iran. Eastern Mediterranean Health Journal, 16(6), 646–650. https://doi.org/10.26719/2010.16.6.646