Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis

Abstract

Objective: To define the significance of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in the septic cascade by comparing its kinetics to those of other proinflammatory mediators and of interleukin (IL) 10. Design: Prospective study in a tertiary unit. Patients: Blood was sampled from 90 patients with septic syndrome due to ventilator-associated pneumonia for 7 days after the appearance of symptoms. Concentrations of tumor necrosis factor (TNF) α, IL-6, IL-8, IL-10, and sTREM-1 were determined by enzyme-linked immunosorbent assay. Results: Serum levels of TNFα, IL-6, IL-10and sTREM-1 were higher in nonsurvivors than in survivors; similar differences were not found for IL-8. Positive correlations were found between the ratios IL-10/TNFα and sTREM-1/TNFα, between IL-10/IL-6 and sTREM-1/IL-6, and between IL-10/IL-8 and sTREM-1/IL-8. Median values of IL-10/TNFα upon presentation of sepsis, severe sepsis, and septic shock were 3.21, 2.16, and 2.86, respectively (NS). Respective values for sTREM-1/TNFα were 21.28, 7.33, and 27.78 (p = 0.047 between sepsis and severe sepsis, p = 0.003 between severe sepsis and septic shock). Conclusions: sTREM-1 follows the kinetics of IL-10 and should therefore be considered an anti-inflammatory mediator in sepsis. Decreased ratios of sTREM-1/TNFα might determine transition from sepsis to severe sepsis and from severe sepsis to septic shock. © Springer-Verlag 2005.