Synthesis Of Optically Pure 2-Aziridinemethanols: Versatile Synthetic Building Blocks

Abstract

Synthesis of three cis-trans pairs of N-sulfonylated-2-aziridinemethanols starting from (S)-threonine, (R)-allothreonine, a chiral 2-amino alcohol, or enantiomerically enriched 2,3-epoxy alcohols is described. A synthetic route to N-tosyl- and N-mesyl-2-aziridinemethanols from (R)- and (S)-serines is also presented. © 1994, The Pharmaceutical Society of Japan. All rights reserved.