Uronium salts from polymeric N-hydroxysuccinimide (P-HOSu) as newsolid-supported peptide coupling reagents

Abstract

The new polymeric uronium salts P-TSTU and P-HSTU have been prepared from polymeric N-hydroxysuccinimide (P-HOSu) and used as solid-supported reagents for peptide coupling reactions. The P-HOSu liberated can be recovered by simple filtration and reused for the preparation of new reagents.