Thirty-fifth anniversary of the optical affinity sensor for glucose: A personal retrospective

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Abstract

Since 1962 when Clark introduced the enzyme electrode, research has been intense for a robust implantable glucose sensor. An alternative optical affinity sensor was introduced by Jerome Schultz in 1979. The evolution of this sensor technology into a new methodology is reviewed. The approach integrates a variety of disparate concepts: the selectivity of immunoassays-selectivity for glucose was obtained with concanavalin A, detection sensitivity was obtained with fluorescence (FITC-Dextran), and miniaturization was achieved by the use of an optical fiber readout system. Refinements of Schultz's optical affinity sensor approach over the past 35 years have led to a number of configurations that show great promise to meet the needs of a successful implantable continuous monitoring device for diabetics, some of which are currently being tested clinically.

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Schultz, J. S. (2015). Thirty-fifth anniversary of the optical affinity sensor for glucose: A personal retrospective. Journal of Diabetes Science and Technology, 9(1), 153–155. https://doi.org/10.1177/1932296814552477

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