Primary lymphoma of nasal cavity and paranasal sinuses

Abstract

Background: There are several reports of lymphomas arising in the nasal cavity, either T cell/NK cell or B cell type. We studied several cases of lymphoma involving the nasal cavity or paranasal sinuses. Method: In our case series, pathology records of patients from 2003 through 2011 revealed 13 cases. The association between Eptsetin-Barr virus (EBV) and lymphoma was studied by immunohistochemistry and PCR methods. Results: The cohort included 9 males and 4 females, aged 16 to 78 years. Histology revealed diffuse large B-cell lymphoma (DLBL) in 7 of the patients, sinonasal extramedullay plasmacytoma, one with follicular lymphoma, one peripheral T-cell lymphoma, one extranodal NK/T-cell lymphoma, and one Burkitt lymphoma. The latent membrane protein (LMP) of EBV was not expressed, and the PCR results were negative, in all patients. Conclusion: In this study, primary lymphomas arising in the nasal cavity were mostly of B cell origin. © 2012 by The American Society for Clinical Pathology.