AMINOGLYCOSIDE ANTIBIOTICS.

Abstract

With regard to biosynthesis, the following is discussed: streptidine, deoxystreptamine, streptomycin, neomycin, paromomycin, vibostamycin, butirosin, gentamicin, micronomicin, sisomicin, fortamine, fortimicins, mutasynthesis. A-Factor, and metabolic grid. With regard to drug manufacture, the following is discussed: fermentation, microorganisms, equipment, inoculum development, media, procedures, and isolation. Finally, strain improvement is briefly examined.