Abstract
We demonstrate a label-free microfluidic immunosensor for early diagnostics of breast cancer (epidermal growth factor receptor or ErbB2) with a detection limit at the level of 1.0 fM. This device utilizes a uniquely structured immunoelectrode made of porous graphene foam (GF) modified by titanium dioxide nanofibers (nTiO2) at its surface. The antibody of ErbB2 acts as a detection probe immobilized on the GF-nTiO2 electrode via EDC-NHS chemistry. This immunosensor provides a high sensitivity of 43.7 kΩ/µM in a wide detection range, good stability, and fast response (3 min) for detection of ErbB2 antigen.
Cite
CITATION STYLE
Ali, M. A., Oren, S., Jiao, Y., Wang, Y., Xu, Z., & Dong, L. (2016). Microfluidic label-free immunochip for early diagnostics of breast cancer using functionalized porous graphene. In 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 (pp. 284–285). Transducer Research Foundation. https://doi.org/10.31438/trf.hh2016.76
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