The thymic cortex provides a microenvironment that supports the generation and T cell antigen receptor (TCR)-mediated selection of CD4(+)CD8(+)TCRαβ(+) thymocytes. Cortical thymic epithelial cells (cTECs) are the essential component that forms the architecture of the thymic cortex and induces the generation as well as the selection of newly generated T cells. Here we summarize current knowledge on the development, function, and heterogeneity of cTECs, focusing on the expression and function of β5t, a cTEC-specific subunit of the thymoproteasome.
CITATION STYLE
Takada, K., Ohigashi, I., Kasai, M., Nakase, H., & Takahama, Y. (2013). Development and Function of Cortical Thymic Epithelial Cells (pp. 1–17). https://doi.org/10.1007/82_2013_322
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