Spectroscopic determination of alkyl resorcinol concentration in hydroxyapatite composite

Abstract

Background: Recently, alkyl resorcinol compounds showed remarkable improvements on dental implant restoration as well as anaesthetic, antiseptic, and anthelmintic applications. In this study, we prepared biologically functional composition of 4-hexylresorcinol (4HR)-loaded hydroxyapatite (HA). Findings: Attenuated total reflectance (ATR) Fourier-transform infrared (FT-IR) spectroscopy fully assigned vibrational absorptions of 4-hexylresorcinol as well as the HA. The absorption coefficient of 4HR aqueous solution is estimated to be 1393 ± 61 cm−1 M−1 at highly diluted concentration. The 4HR was loaded with 0.018 % (wt/wt) in the 4HR-HA composite. Conclusions: We quantitatively determined the micromolar concentration of 4HR loaded in the composite based on ultraviolet-visible (UV-Vis) absorption spectroscopy.