Abstract
Two carbonic anhydrase IX (CA IX) inhibitors were radiolabeled with 18F, and evaluated for imaging CA IX expression. Despite good affinity for CA IX and excellent plasma stability, uptake of both tracers in CA IX-expressing HT-29 tumor xenografts in mice was low. 18F-FEC accumulated predominately in the liver and nasal cavity, whereas a significant amount of 18F-U-104 was retained in blood. Due to minimal uptake in HT-29 tumors compared to other organs/tissues, these two tracers are not suitable for use for CA IX-targeted imaging. © 2014 Informa UK Ltd. All rights reserved.
Author supplied keywords
Cite
CITATION STYLE
Pan, J., Lau, J., Mesak, F., Hundal, N., Pourghiasian, M., Liu, Z., … Lin, K. S. (2014). Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography. Journal of Enzyme Inhibition and Medicinal Chemistry, 29(2), 249–255. https://doi.org/10.3109/14756366.2013.773994
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
