Risk factors of cardiac complications in patients with end-stage renal disease undergoing maintenance peritoneal dialysis

Abstract

Background: Cardiovascular disease (CVD) is the most frequent cause of death in patients on maintenance peritoneal dialysis (PD). This study aimed to identify the risk factors associated with cardiac complications and establish a multivariate logistic regression model for cardiac complications in patients with end-stage renal disease (ESRD) requiring PD. Methods: This retrospective study included 232 patients undergoing PD. Data of sociodemographic information, comorbidities, medication history, laboratory examination, and medical history were extracted from the medical records of patients with ESRD who underwent maintenance PD between January 2015 and June 2020. Multivariate logistic regression analysis was performed to determine the independent risk factors. Results: The mean age of the study participants was 51.29±13.17 years, with female: male ratio of 87:145. Multivariate logistic regression analysis indicated that lactate dehydrogenase (odds ratio, 1.002; 95% confidence interval, 1.001–1.004; P=0.004), albumin (odds ratio, 0.947; 95% confidence interval, 0.914–0.982; P=0.003), and left atrial diameter (odds ratio, 1.096; 95% confidence interval, 1.037–1.159; P=0.001) were independent risk factors associated with cardiac complications. The area under the receiver operating characteristic curve was 0.78. Conclusions: We identified the risk factors of cardiac complications in patients with ESRD requiring PD, which may be clinically useful to assess patients in PD and start their early treatment, which can help improve their prognosis.