Abstract
Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.
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Lee, J. H., Lim, Y. B., Choi, J. S., Choi, M. U., Yang, C. H., & Park, J. S. (2003). Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences. Bulletin of the Korean Chemical Society, 24(11), 1637–1640. https://doi.org/10.5012/bkcs.2003.24.11.1637
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