The most used claisen rearrangements in organic synthesis: A review

Abstract

This manuscript is a literature review of major [3,3]-sigmatropics rearrangements, but specifically Claisen rearrangement, commonly used in organic synthesis over the past 16 years. Rearranged products result from a thermodynamic stability facet. In pericyclic reactions the term "sigmatropic shift" or "sigmatropic rearrangement" is better suited than rearrangement. Claisen's rearrangements are among the most well-known pericyclic reactions governed by the Woodward- Hoffmann rules. The principles of Claisen rearrangements and their mechanisms are treated in the present study.