High flux hemodialysis in elderly patients with chronic kidney failure

Abstract

BACKGROUND Hemodialysis is an advanced blood purification technique to manage kidney failure. However, for conventional hemodialysis, the high prevalence of dyslipidemia may cause cardiovascular diseases and an increase in mortality. Moreover, toxins accumulating in the body over time may induce some complications. High flux hemodialysis can effectively improve disease indexes and clinical symptoms. AIM To investigate the efficacy of high flux hemodialysis in elderly patients with chronic kidney failure (CKF). METHODS A total of 66 elderly patients with CKF who were admitted to our hospital from October 2017 to October 2018 were included in the study. According to the therapies they received, the patients were divided into a study group and a control group with 33 patients in each group. The study group received high flux hemodialysis and the control group received conventional dialysis treatment. Kidney function, toxin levels in serum, and complications were compared in the two groups. RESULTS Before the treatment, there was no significant difference in kidney function, β2-microglobulin, or blood urea nitrogen between the two groups (P > 0.05). In contrast, kidney function was better in the study group than in the control group after the treatment (P < 0.05). In addition, the study group had significantly lower parathyroid hormone and serum cystatin C than the control group (P < 0.05). The incidence of complications was 8.57% in the study group, which was lower than that of the control group (20.00%; P < 0.05). CONCLUSION High flux hemodialysis may improve kidney function and reduce toxin levels in serum and the incidence of complications in elderly patients with CKF.