Mannose-binding lectin binds to amyloid protein and β modulates inflammation

22Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Mannose-binding lectin (MBL), a soluble factor of the innate immune system, is a pattern recognition molecule with a number of known ligands, including viruses, bacteria, and molecules from abnormal self tissues. In addition to its role in immunity, MBL also functions in the maintenance of tissue homeostasis. We present evidence here that MBL binds to amyloid peptides. MBL binding to other known carbohydrate ligands is calcium-dependent and has been attributed to the carbohydrate-recognition domain, a common feature of other C-type lectins. In contrast, we find that the features of MBL binding to A are more similar to the reported binding characteristics of the cysteine-rich domain of the unrelated mannose receptor and therefore may involve the MBL cysteine-rich domain. Differences in MBL ligand binding may contribute to modulation of inflammatory response and may correlate with the function of MBL in processes such as coagulation and tissue homeostasis. Copyright © 2012 Mykol Larvie et al.

References Powered by Scopus

Alzheimer's disease: The amyloid cascade hypothesis

6018Citations
N/AReaders
Get full text

The molecular pathology of Alzheimer's disease

2383Citations
N/AReaders
Get full text

Phylogenetic perspectives in innate immunity

2240Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The role of protein glycosylation in Alzheimer disease

262Citations
N/AReaders
Get full text

Omega-3 fatty acids enhance phagocytosis of alzheimer's disease-related amyloid-β<inf>42</inf> by human microglia and decrease inflammatory markers

195Citations
N/AReaders
Get full text

Alzheimer's associated β-Amyloid protein inhibits influenza a virus and modulates viral interactions with phagocytes

157Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Larvie, M., Shoup, T., Chang, W. C., Chigweshe, L., Hartshorn, K., White, M. R., … Takahashi, K. (2012). Mannose-binding lectin binds to amyloid protein and β modulates inflammation. Journal of Biomedicine and Biotechnology, 2012. https://doi.org/10.1155/2012/929803

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 16

50%

Researcher 14

44%

Professor / Associate Prof. 2

6%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 12

44%

Biochemistry, Genetics and Molecular Bi... 6

22%

Chemistry 5

19%

Medicine and Dentistry 4

15%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 9

Save time finding and organizing research with Mendeley

Sign up for free