Extensive preclinical and clinical investigations indicate that iron, mobilized from serum, body tissues, and brain, causes neurotoxic effects in cerebral ischemia and hemorrhage. Iron plays a role in neuronal injury by catalyzing oxidative reactions that yield highly reactive toxic hydroxyl radicals leading to oxidative stress and cell death, activating lipid peroxidation, and exacerbating excitotoxicity. Deferoxamine (DFO), a powerful iron chelator, has been demonstrated in experimental stroke models as an effective neuroprotective agent by multiple and diverse mechanisms, principally by limitation of iron-mediated neurotoxicity but also by non-iron-mediated effects. This chapter reviews the experimental and clinical data existing about the neuroprotective role of iron chelators, especially DFO, in brain ischemia and hemorrhage.
CITATION STYLE
Millan, M., Pérez de la Ossa, N., & Gasull, T. (2012). Iron-chelating therapy in stroke. In Metal Ion in Stroke (pp. 283–301). Springer New York. https://doi.org/10.1007/978-1-4419-9663-3_14
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