Functional resting-state network disturbances in bipolar disorder

Abstract

This section overviews a large panel of studies investigating brain function at rest in bipolar disorder patients using various approaches. Literature findings highlight abnormal functional connectivity patterns within and between several brain networks including default mode, control, and saliency networks. Local and large-scale connectivity changes in these networks as well as modulation of cortico-striato-thalamic, reward-related, and sensorimotor circuits might depend on patients' symptomatology. Further studies should clarify specific associations between clinical dimensions and functional network properties.