Abstract
99mTc-tricarbonyl chemistry provides an elegant technology to site-specifically radiolabel histidine-tagged biomolecules. Considering their unique biochemical properties, this straightforward technology is particularly suited for Nanobodies. This chapter gives a detailed guide to generate highly specific Nanobody-derived radiotracers for both in vitro binding studies and in vivo molecular imaging. © 2012 Springer Science+Business Media, LLC.
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Xavier, C., Devoogdt, N., Hernot, S., Vaneycken, I., D’Huyvetter, M., De Vos, J., … Caveliers, V. (2012). Site-specific labeling of his-tagged nanobodies with 99mTc: A practical guide. Methods in Molecular Biology, 911, 485–490. https://doi.org/10.1007/978-1-61779-968-6_30
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