Noninvasive acoustic manipulation of objects in a living body

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Abstract

In certain medical applications, transmitting an ultrasound beam through the skin to manipulate a solid object within the human body would be beneficial. Such applications include, for example, controlling an ingestible camera or expelling a kidney stone. In this paper, ultrasound beams of specific shapes were designed by numerical modeling and produced using a phased array. These beams were shown to levitate and electronically steer solid objects (3-mm-diameter glass spheres), along preprogrammed paths, in a water bath, and in the urinary bladders of live pigs. Deviation from the intended path was on average <10%. No injury was found on the bladder wall or intervening tissue.

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Ghanem, M. A., Maxwell, A. D., Wang, Y. N., Cunitz, B. W., Khokhlova, V. A., Sapozhnikov, O. A., & Bailey, M. R. (2020). Noninvasive acoustic manipulation of objects in a living body. Proceedings of the National Academy of Sciences of the United States of America, 117(29), 16848–16855. https://doi.org/10.1073/pnas.2001779117

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