The dicyclohexylamine salt of RG108 (N-phthalyl-L-tryptophan), a potential epigenetic modulator

Abstract

The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water molecule and a disordered molecule of dimethyl-formamide (DMF), viz. dicyclo-hexyl-aminium (S)-2-(1,3-dioxoisoindolin- 2-yl)-3-(1H-indol-3-yl)propanoate dimethyl-formamide solvate monohydrate, C 12H24N+·C19H 13N2O4-·C3H 7NO·H2O. The conformation of the deprotonated compound is constrained by charge-assisted strong hydrogen bonds with the dicyclo-hexyl-aminium ion and a dense hydrogen-bond network involving co-crystallized solvent molecules. The dihedral angle between the fused ring systems in the anion is 58.35 (4)°.