Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt diagnosis and intervention. The duration of each flare-up and intervals between the pustular episodes is extremely variable. Recently, genetic abnormalities have been identified mainly in the familial and early variants of this disease. The therapeutic arsenal is limited; however, new drugs being evaluated aim to control both pustular flare-ups and disease recurrences.
CITATION STYLE
Romiti, R., Hirayama, A. L. da S., Arnone, M., & Magalhães, R. F. (2022, January 1). Generalized pustular psoriasis (von Zumbusch). Anais Brasileiros de Dermatologia. Elsevier Espana S.L.U. https://doi.org/10.1016/j.abd.2021.05.011
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