Subcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections. We herein present a case of a 40-year-old woman with type 2 diabetes mellitus who had been diagnosed with subcutaneous insulin resistance syndrome since the age of 29 years, and had been persistently treated with continuous subcutaneous insulin infusion using a mixture of insulin lispro and heparin. The patient was switched from insulin lispro plus heparin to ultra-rapid insulin lispro; given that it contains treprostinil and citrate, it is expected to have similar effects as heparin, and shows similar glucose-lowering effects and insulin absorption. Our results suggest that treatment with ultra-rapid insulin lispro is effective for subcutaneous insulin resistance syndrome.
CITATION STYLE
Ishii, T., Katayama, A., Sue, M., Kuribayashi, R., Tenta, M., Matsushita, Y., … Hida, K. (2022). Case of subcutaneous insulin resistance syndrome treated with ultra-rapid insulin lispro. Journal of Diabetes Investigation, 13(3), 588–591. https://doi.org/10.1111/jdi.13667
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