Antibacterial activity of coumarine derivatives synthesized from 4-Chloro-chromen-2-one. The comparison with standard drug

Abstract

This work reports the synthesis of some new derivatives from 4-Chloro-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-Butylamino-chromen-2-one (1a) , 4-Butylamino-2-oxo-2H-chromene-3-sulfonyl chloride (2a) , 4-Butylamino-2-oxo-2H-chromene-3-sulfonic acid (2-hydroxy-phenyl)-amide (3a), 4-Butylamino-5-ethyl-2-oxo-7-(N′-phenyl-hydrazino)-2H-chromene-3-sulfonic acid (2-hydroxy-phenyl)-amide (4a), have been synthesized and characterized using melting points, IR spectra, 1 H-NMR and 13 C-NMR spectra. The antibacterial activity of synthesized compounds and streptomycin at concentractions of 1mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E.coli and Klebsiella. The compounds show bacteriostatic and bactericidal activity.