Reactive oxygen species (ROS) likely play a role in the hypoxic ventilatory response. We determined whether hypoxic responses were influenced by alterations in cellular redox status induced by reductions in superoxide dismutase-1 (SOD-1) activity, a cytosolic anti-oxidant enzyme. Using whole-body, continuous-flow plethysmography, we compared ventilatory responses to moderate hypoxia (10% inspired O2) of Sod1+/+, +/- and -/- postnatal day 4 (P4) littermates. Sod1+/- neonates exhibited a consistently lower breathing frequency than their wild-type littermates, regardless of inspired O2 level. While SOD-1 deficiency had no effect on the magnitude of the ventilatory response during hypoxia, it did compromise stability of breathing in the post-hypoxic period. Our results suggest SOD-1 stimulates ventilation and helps stabilize breathing after a hypoxic perturbation. © 2008 Springer Science+Business Media, LLC.
CITATION STYLE
Cummings, K. J., Kalf, D., Moore, S., Miller, B. J., Jirik, F. R., & Wilson, R. J. A. (2008). Superoxide dismutase-1 influences the timing and post-hypoxic stability of neonatal breathing. In Advances in Experimental Medicine and Biology (Vol. 605, pp. 133–138). https://doi.org/10.1007/978-0-387-73693-8_23
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