Abstract
Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 μg/mL, respectively.
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Astulla, A., Hirasawa, Y., Rahman, A., Kusumawati, I., Ekasari, W., Widyawaruyanti, A., … Morita, H. (2011). Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia. Natural Product Communications, 6(3), 323–326. https://doi.org/10.1177/1934578x1100600304
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