Polymorphism of doxazosin mesylate

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Abstract

Nine polymorphic modifications of doxazosin mesylate have been obtained by recrystallization in organic solvents under variable conditions. Different polymorphs of doxazosin mesylate were characterized by powder X-ray crystallography diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). Transformation of Form 1 and Form 2 was not occurred in three relative humidities (0%, 51%, and 99%) at 20±0.5 for 30 days.

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Sohn, Y. T., & Lee, Y. H. (2005). Polymorphism of doxazosin mesylate. Archives of Pharmacal Research, 28(6), 730–735. https://doi.org/10.1007/BF02969365

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