Cervicocogenic headache (CeH) is a relatively common disorder Although no ideal treatment is available so far, blockades in different structures and nerves may be temporarily effective. We studied the effects of 1-2 mL 0.5% bupivacaine injection at the ipsilateral greater occipital nerve (GON) in 41 CeH patients The pain is significantly reduced both immediately and as long as 7 days after the blockade. The improvement is less marked during the first two days, a phenomenon we called "tilde pattern". GON blockades may reduce the pool of exaggerated sensory input and antagonize a putative "wind-up-like effect" which may explain the headache improvement.
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Vincent, M. B., Luna, R. A., Scandiuzzi, D., & Novis, S. A. P. (1998). Greater occipital nerve blockade in cervicogenic headache. Arquivos de Neuro-Psiquiatria, 56(4), 720–725. https://doi.org/10.1590/S0004-282X1998000500004