Development of nanoparticle-enabled protein biomarker discovery: Implementation for saliva-based traumatic brain injury detection

Abstract

In this chapter we will discuss a new approach for amplifying low-abundance proteins for biomarker discovery and how this new approach can be applied to identifying new markers for the detection of traumatic brain injury (TBI) and concussion. Of particular focus is the discovery of nonsubjective, sensitive, and specifi c biomarkers for early detection of TBI/concussion that can be quantifi ed accurately and which can be measured in an easily obtainable biofl uid. We propose that such a method can be applied to TBI detection in saliva-a biofl uid that heretofore has not been considered for this application.