Post-transfusion hypertension and seizure in congenital hemolytic anemia: A case report and literature review

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Abstract

A rare syndrome of hypertension, seizures and intracranial bleed has been reported among patients with congenital hemolytic anemia who underwent multiple blood transfusions. We report this syndrome in a 12-year-old Malay girl with hemoglobin E-beta-thalassemia, who underwent intensive transfusion and subsequently had headache, visual loss, severe hypertension and seizures. A comprehensive literature review revealed 30 patients with this syndrome, of whom 15 had intracranial bleed and 12 among these 15 died. A less-intensive transfusion regimen among patients with chronic hemolytic anemia and prompt detection and management of hypertension may prevent this potentially fatal syndrome. © The Author [2014].

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Ngim, C. F., Ng, C. S., & Lai, N. M. (2014). Post-transfusion hypertension and seizure in congenital hemolytic anemia: A case report and literature review. Journal of Tropical Pediatrics, 60(3), 253–256. https://doi.org/10.1093/tropej/fmu003

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