The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
CITATION STYLE
Curtin, C. M., Cunniffe, G. M., Lyons, F. G., Bessho, K., Dickson, G. R., Duffy, G. P., & O’Brien, F. J. (2012). Innovative collagen nano-hydroxyapatite scaffolds offer a highly efficient non-viral gene delivery platform for stem cell-mediated bone formation. Advanced Materials, 24(6), 749–754. https://doi.org/10.1002/adma.201103828
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