The history of hypothermia therapy for perinatal ischemic brain injury

Abstract

Firstly, I mention on pathology of ischemic brain injury, including experimental history of hypothermia. Next, I explain about how clinical trial study starts and proceed to Consensus 2010 in which hypothermia therapy should be recommended for newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE). Next I talk about how hypothermia therapy spreads and could be standardized on the guideline and nationwide online registry system in Japan since Consensus 2010. I explain about some rq`esearch works about efficacy and criteria of hypothermia therapy. I also introduce unique research about how to control core temperature during transportation in Japan. Finally, I talk about the possibility to start new neuroprotective therapy for newborns with perinatal ischemic brain injury.