Aggregation of MHC class I molecules on a CD8+ αβ T cell clone specifically inhibitis non-antigen-specific lysis of targel cells

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Abstract

MHC class I molecules are target molecules recognized by TCR or NK receptors encoded in the NK gene cluster or leukocyte receptor cluster. We show that aggregation of MHC class I molecules by specific monoclonal antibodies on cytotoxic T cells, inhibits the anti-CD94 redirected lysis of P815. This inhibition is not the consequence of apoptosis or anergy of the cytotoxic T lymphocytes. In contrast, aggregation of MHC class I molecules does not inhibit either the anti-CD3 redirected cytotoxicity or the CD94-triggered up-regulation of CD25 molecules of the same T cell clone. MHC class I ligand molecules expressed by antigen presenting cells and/or T lymphocytes could therefore be able to modulate nonspecific cytotoxicity upon interaction with MHC class I molecules expressed by effector cytotoxic T lymphocytes.

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Caparrós, E., de Heredia, A. B., Carpio, E., Sancho, D., Aguado, E., & Aparicio, P. (2004). Aggregation of MHC class I molecules on a CD8+ αβ T cell clone specifically inhibitis non-antigen-specific lysis of targel cells. European Journal of Immunology, 34(1), 47–55. https://doi.org/10.1002/eji.200324462

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