Recurrent immune reconstitution inflammatory syndrome of tuberculous brain infection in people living with HIV/AIDS: A case report

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Abstract

HIV infection has changed the scenario of infectious disease. HIV-associated immunodeficiency resulted in a wide spectrum of new opportunistic infections. After introduction of antiretroviral therapy (ART), immune reconstitution inflammatory syndrome (IRIS) became an important challenge in management of 10% to 25% of the patients. Meta-analyses of IRIS from various reports published worldwide by Monika Muller et al described 12% IRIS incidence and 15.7% IRIS tuberculosis. Among IRIS tuberculosis, central nervous system involvement with IRIS tuberculous meningitis forms only 7%. Only 9 cases of tuberculous brain abscess is reported in patients with AIDS so far. The IRIS tuberculous brain abscess is very rare, and so far only 1 case is reported as a paradoxical reaction after ART initiation. Here, we report a case of recurrent IRIS tuberculosis meningitis and brain abscess. © The Author(s) 2013.

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Krishnaraj, R., Chokkalingam, C., Krishnarajasekhar, O. R., Narayanan, R., Sadagopan, K., & Ayyamperumal, M. (2014). Recurrent immune reconstitution inflammatory syndrome of tuberculous brain infection in people living with HIV/AIDS: A case report. Journal of the International Association of Providers of AIDS Care, 13(1), 15–17. https://doi.org/10.1177/2325957413488170

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