Role of Thiols in Radioprotection: Radiation Chemical Aspects

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Abstract

Using the technique of pulse radiolysis, it has been demonstrated that thiyl radicals(RS.) derived from glutathione (GSH), cysteine (CYSH), penicillamine (PnSH) and 2-mercaptoethanol (ME) interact with oxygen at a high rate. The resulting transient absorption. with a maximum around 540-560 nm, is characteristic of the sulphur peroxyl radical (RSOO.). The yield and the kinetic of formation of RSOO further support our previous suggestion that thiyl/O2 reaction is an equilibrium. The redox properties of RSOO. are discussed on the basis of the interaction with reductants. Studies on the radio-induced enzyme inactivation in the presence of thiols seem to suggest a damaging role for RSOO. radicals. © 1989, Verlag der Zeitschrift. All rights reserved.

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Tamba, M. (1989). Role of Thiols in Radioprotection: Radiation Chemical Aspects. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 44(9–10), 857–862. https://doi.org/10.1515/znc-1989-9-1027

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