Multimodality molecular imaging continues to rapidly expand and is impacting many areas of biomedical research as well as patient management. Reporter-gene assays have emerged as a very general strategy for indirectly monitoring various intracellular events. Furthermore, reporter genes are being used to monitor gene/cell therapies, including the location(s), time variation, and magnitude of gene expression. This chapter reviews reporter gene technology and its major pre-clinical and clinical applications to date. The future appears quite promising for the continued expansion of the use of reporter genes in many evolving biomedically related arenas. © 2008 Springer Berlin Heidelberg.
CITATION STYLE
Min, J. J., & Gambhir, S. S. (2008). Molecular imaging of PET reporter gene expression. Handbook of Experimental Pharmacology, 185(PART2), 277–303. https://doi.org/10.1007/978-3-540-77496-9_12
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