A local basis for progesterone action during mammary tumorigenesis - no longer RANK and file

Abstract

Two recent reports provide compelling insights into the role for RANK and its ligand, RANKL, in progestin-dependent mammary tumorigenesis. These findings build upon a considerable body of evidence pointing to the RANK signaling pathway as being a key mediator of progestin action in the mammary glands. © 2011 BioMed Central Ltd.