Non-invasive quantification of diaphragm kinetics using m-mode sonography

Abstract

Purpose: The standard conditions of spirometry (i.e., wearing a noseclip and breathing through a mouthpiece and a pneumotachograph) are likely to alter the ventilatory pattern. We used 'time-motion' mode (M-mode) sonography to assess the changes in diaphragm kinetics induced by spirometry during quiet breathing. Methods: An M-mode sonographic study of the right diaphragm was performed before and during standard spirometry in eight patients without respiratory disease (age 34 to 68 yr). Results: During spirometry, the diaphragm inspiratory amplitude (DIA) increased from 1.34 ± 0.18 cm to 1.80 ± 0.18 cm (P = 0.007), whereas the diaphragmatic inspiratory time (T1 diaph) increased from 1.27 ± 0.15 to 1.53 ± 0.23 sec, (P = 0.015), without change in diaphragmatic total time interval (Ttot diaph). Therefore, the diaphragm duty cycle (T1 diaph/Ttot diaph) increased from 38% ± 1% to 44% ± 4% (P = 0.023). The diaphragm inspiratory (DIV) and expiratory (DEV) motion velocity increased (P = 0.007). Conclusion: M-mode sonography enabled us to demonstrate that the wearing of a nose clip and breathing through a mouthpiece and a pneumotachograph induce measurable changes in diaphragm kinetics.