Genetics and functional genomics of type 2 diabetes mellitus

Abstract

Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCGIα. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus.