Antioxidant effect of MnTE-2-PyP on lung in asthma mice model

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Abstract

Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model. © 2012 Lyudmil Terziev et al.

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Terziev, L., Dancheva, V., Shopova, V., & Stavreva, G. (2012). Antioxidant effect of MnTE-2-PyP on lung in asthma mice model. The Scientific World Journal, 2012. https://doi.org/10.1100/2012/379360

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