Synthesis, Characterization and Biological Activity of Two Novel transition metal complexes of pyrazolone

Abstract

Using 2-hydrazinopyridine, dimethyl butynedioate and sodium methoxide as raw materials, a new pyridine-pyrazolone derivative containing multiple nitrogen coordination atoms was synthesized through a multi-step reaction, namely the ligand 1-(2-pyridine)-5-hydroxyl -1H-pyrazole-3-carboxylic acid methyl ester (HL). Using solvothermal method, two novel transition metals Co and Zn complexes of pyrazolone were synthesized. The structures were characterized by infrared spectroscopy, XRD and X-ray single crystal diffraction. Notably, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay showed that 2 displayed relatively high cytotoxic activity against Hep-G2 and MGC80-3 cancer cells.