Determination and evaluation of acid dissociation constants of some novel benzothiazole schiff bases and their reduced analogs by spectroscopy

Abstract

The acid dissociation constants (Ka) of eight novel biologically active benzothiazole Schiff bases were determined by UV-vis spectroscopic technique at 25 ± 0.1 °C. The calculated acidity constants, pK a values, were evaluated in structure elucidation and protonation - deprotonation mechanisms. The prototropic tautomerism was also studied.