Effects of fish Oil on HIV-Related inflammation and markers of immunosenescence: A randomized clinical trial

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Abstract

Objective: To explore the safety and efficacy of fish oil to modulate parameters of inflammation and immunosenescence in HIV-infected older adults. Design: This study uses a randomized, controlled, double-blind clinical trial. Setting: The study was conducted in an outpatient HIV/AIDS clinic in a large urban Midwestern city in the United States. Subjects: A total of 37 clinically stable HIV-infected adults between the ages of 40 and 70 years of age participated. Interventions: Fish oil 1.6 g/day was administered for 12 weeks or placebo. Outcome measures: Inflammatory cytokine production, surface markers of immunosenescence, and adverse events were measured. Results: After 12 weeks of supplementation, there were no significant differences between the treatment and control groups on any measures of inflammation or immunosenescence in both CD4+ and CD8+ T lymphocytes. More participants in the treatment group reported adverse gastrointestinal events compared with the control group. Conclusions: A 12-week supplementation regimen of 1.6 g/day of fish oil did not favorably modulate parameters of inflammation or immune senescence in HIV-infected adults. Future studies should test agents that directly target mechanisms that underlie HIV-related inflammation to determine whether reducing inflammation can reverse immunosenescence.

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Swanson, B., Keithley, J., Baum, L., Leurgans, S., Adeyemi, O., Barnes, L. L., … Rosdil, A. (2018). Effects of fish Oil on HIV-Related inflammation and markers of immunosenescence: A randomized clinical trial. Journal of Alternative and Complementary Medicine, 24(7), 709–716. https://doi.org/10.1089/acm.2017.0222

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