Haemorrhage Involving the Central Nervous System in Haemophilia: Account of the Management of Five Cases

Abstract

A report of the management of five cases of haemophilia with haemorrhage involving the central nervous system is given. Four of these made a good recovery ; one died. The conservative diagnostic approach is emphasized, avoiding the routine procedures available to patients with no coagulation defects. Treatment was with infusions of fresh plasma and A.H.G. and Christmas factor concentrates. Although deterioration in the clinical condition was halted with fresh plasma, recovery rapidly followed the use of concentrates. These have the added advantages of greater potency and less bulk, both of importance in preventing further haemorrhage. This treatment on the whole compares favourably with previous reports of treatment in this condition (Silverstein, 1960 ; Kerr, 1964). © 1966, British Medical Journal Publishing Group. All rights reserved.