An update on carbonic anhydrase-related proteins VIII, X and XI

30Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The catalytically inactive isoforms of carbonic anhydrase (CAs) are known as CA-related proteins (CARPs) VIII, X, and XI. They have highly conserved amino acid sequences. These proteins are predominantly expressed in human and mouse brain, however, their precise roles are poorly known. CARP VIII is functionally associated with motor coordination in human and mouse. CARP X is more highly expressed in the pineal gland during night compared to the day time, suggesting a function for wake/sleep patterns. Phylogeny shows that CARP XI has emerged from CARP X. It is only found in tetrapods and is highly expressed in the central nervous system (CNS) of humans and is also associated with several cancers. Detailed analysis of CARPs is in progress in our laboratory to understand their role in normal physiology. We present a review of literature on CARPs and present some novel data on CARPs obtained in our laboratory. © 2013 Informa UK, Ltd.

Cite

CITATION STYLE

APA

Aspatwar, A., Tolvanen, M. E. E., & Parkkila, S. (2013, December). An update on carbonic anhydrase-related proteins VIII, X and XI. Journal of Enzyme Inhibition and Medicinal Chemistry. https://doi.org/10.3109/14756366.2012.727813

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free