Hi-C is a methodology developed to reveal chromosomal interactions from a genome-wide perspective. Here, we described a protocol for generating Hi-C sequencing libraries in resting and activated human naive CD4 T cells to investigate activation-induced chromatin structure re-arrangement in T cell activation followed by a section reviewing the general concepts of Hi-C data analysis.
CITATION STYLE
Meng, X., Riley, N., Thompson, R., & Sharma, S. (2018). Investigate global chromosomal interaction by Hi-C in human naive CD4 T cells. In Methods in Molecular Biology (Vol. 1712, pp. 239–252). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7514-3_15
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