Diagnostics of coronary stenosis: Analysis of arterial blood pressure and mathematical modeling

Abstract

Severity of the coronary stenoses and necessity of the percutaneous coronary intervention is usually estimated basing on analysis of the pressure and flow signals measured in vivo by a pressure gauge at certain distances before and after the stenosis. In the paper the differences in the pressure gradients at different stenosis severity are shown and discussed. A method of decomposition of the measured biosignals into the mean and oscillatory components is proposed. A mathematical model of the steady and pulsatile flow through the viscoelastic blood vessel in the presence of the rigid guiding wire is developed for biomechanical interpretation of the measured coronary blood pressure and flow signals. A novel approach for estimation the stenotic severity basing on the measured and computed data is proposed.