Hematologic changes and hemoglobin analysis in β Thalassemia heterozygotes during the first year of life

Abstract

We have studied the hematology and hemoglobin patterns of normal and heterozygous β thalassemia infants in serial samples obtained during the first year of life. The hemoglobin level, mean cell volume and mean cell hemoglobin were significantly lower in the ft thalassemia traits by the age of 3 months and this difference was maintained throughout the first year. Hb A2 levels were significantly higher in the β thalassemia group but increased in both groups throughout the first year. Hb F levels were also higher in heterozygotes for β thalassemia at all ages, showing a delay in the postnatal decline. Speculation: The low mean cell hemoglobin, elevated Hb F level and increased susceptibility to oxidant damage which characterise the red cells of heterozygous β thalassemia infants may combine to protect these infants against P. falciparum malaria. © 1982 International Pediatric Research Foundation, Inc.