Urinary prostaglandins in the lyon strains of hypertensive, normotensive, and low blood pressure rats

Abstract

A longitudinal study of the urinary excretion of prostaglandins (PCs) E and Fa was performed in simultaneously selected hypertensive (LH), normotensive (LN), and low blood pressure (LL) female rats of the Lyon strains aged from 5 to 45 weeks. The urinary excretion of PGE did not significantly differ between LL and LN rats whereas in LH rats it was found to be significantly lower than that of LN or LL rats starting at the age of 32 weeks. The urinary excretion of PGFa was significantly reduced in both LL and LH rats; however, this decrease was more marked in LH than in LL animals and, from 9 weeks of age, the urinary PGFa were significantly lower in LH than in age-matched LL rats. In addition, both PGE and PGFa were found to be significantly and negatively related to the systolic blood pressure level in LH rats (r10-0.56, n = 58, p < 0.001 for PGE; and r = -0.78, n – 58p < 0.001 for PGFa) but not in LN or LL animals. In conclusion, it seems unlikely that renal PCs could play a primary role in the spontaneous hypertension observed in the Lyon strain of rats. © 1982 American Heart Association, Inc.