Synthesis and antitumor activity of 5′-deoxy-4′-thio-l- nucleosides

Abstract

A series of novel 5′-deoxy-4′-thio-l-nucleosides was designed and synthesized. The absolute configuration of the target compound 23α was confirmed by X-ray crystallography. The antitumor activities of the target compounds were tested against the growth of human carcinoma of colon (LOVO), human leukemia cell line (CEM) and human breast cancer cell line (MDA-MB-435) cells in vitro. 6-cyclopentylamino and 6-cyclohexylamino purine compounds 26 and 27, both in α-configuration and in β-form, exhibited strong inhibition to CEM. © 2010 John Wiley & Sons A/S.